Emanuela de Paula was born to a White Brazilian mother and an Afro Brazilian father. "I am what we call 'mulata'". She has stated to be one of the few models to represent Black women in the fashion industry.
She first took an interest in modeling at the age of nine and quickly booked a supermarket advertisement. By the age of 15, de Paula was visiting modeling agencies. She signed with the Marilyn Agency, the first agency she visited. Her first season was in New York City in 2005, and yielded runway work for the likes of Ralph Lauren, Bill Blass and Zac Posen, as well as a story for W, photographed by Michael Thompson. Her other runway credits include Alexandre Herchcovitch, Colcci, Diane von Furstenberg, Jennifer Lopez' Sweetface, Kenneth Cole, Lacoste, Lucy In The Sky, Rebecca Taylor, Salinas, Tommy Hilfiger, and Yigal Azrouël, and she has appeared in campaigns for Alexandre Herchcovitch, the Swedish brand Gina Tricot, Cavalera, DKNY, GAP Body, Hush Puppies, MAC, Mixed, Prescriptives, Sephora, Tommy Hilfiger, Top Shop, and Victoria's Secret. Her editorials include Allure, French, Marie Claire, Vogue, and Women's Wear Daily.
By the age of 20, de Paula had landed two makeup campaigns: MAC Barbie Collection and Prescriptives. She walked in the Victoria's Secret Fashion Show in 2008 and 2010. According to Forbes, de Paula ranked the eleventh highest paid supermodel for 2009, earning $2.5 million. She currently resides in New York City, and has walked runway for São Paulo Fashion Week, home to the largest fashion shows in Brazil.
She has been praised by Naomi Campbell and Anna Wintour of Vogue.
She was in the Next autumn/winter 2010 campaign and in its TV advert that launched on September 10, alongside Jon Kortajarena.